Oxiracetam Package Insert

ALSO KNOWN AS 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide, 4-Hydroxy-2-oxopyrrolidine-N-acetamide, 4-hydroxy-2-oxo-pyrrolidinoacetamide, ISF 2522, Oxiracetamum, 4-hydroxypiracetam
TRADE NAMES Neuromet, Bei Qing Xing, Jiang Lang Xing, Neuracetam, Neuromed, Neuropia, Ou Lai Ning, Ou Lan Tong
CATEGORY Nootropic, Racetam, Ampakine
TYPE Nootropic Agent, Central Stimulant, Cognitive Enhancer, Psychotropic Drugs
MEDICAL USES
  • Senile Dementia of the Alzheimer’s type
  • Multi-Infarct and Mixed Dementia
  • Memory Dysfunction
  • Organic Brain Syndrome
  • Post-Concussion Syndrome
  • Traumatic Brain Injury
  • Organic Solvent Exposure
NON-MEDICAL USES
  • Nootropic
  • Cognitive Enhancement
  • Logical Thinking
  • Attention Switching
  • Spatial Reasoning
  • Focus & Concentration
  • Studying & Academic Performance
MECHANISM OF ACTION
  • Facilitates cholinergic neurotransmission
  • Positive modulator of AMPA glutamate receptors
  • Increases levels of glutamate release
  • May increase ATP levels and stimulate arousal
  • Increases membrane phospholipid synthesis
  • Promotes proper function of blood-brain barrier
DOSAGE 400 mg to 2400 mg per day, split into 1 – 2 administrations
STACKED WITH Piracetam, Pramiracetam, Aniracetam, Phenylpiracetam, Noopept, Choline, Alpha GPC, Citicoline, Centrophenoxine, DMAE, Phosphatidylcholine, Adderall, Modafinil (Provigil), Phenibut
ATC CODE N06BX07 (WHO): N06 Psychoanaleptics > NO6B Psychostimulants, agents used for adhd and nootropics > NO6BX Other psychostimulants and nootropics
CAS REGISTRY NUMBER 62613-82-5
CHEMICAL FORMULA C6H10N2O3
CHIRALITY Racemic mixture
MOLECULAR WEIGHT 158.157 g/mol
ADMINISTRATION Oral, Intravenous
ABSOPRTION Absorbed from the gastrointestinal tract over 1-3 hours
ABSOLUTE BIOAVAILABILITY 68-85%
METABOLITES
  • Not extensively metabolized; up to 90% excreted in urine as intact molecule
  • Beta-hydroxy-2-pyrrolidone
  • N-aminoacetyl-GABOB
  • GABOB (beta-hydroxy-GABA)
  • Glycine
EXCRETION
  • Renal
  • Urine (84-90%)
BIOLOGICAL HALF-LIFE 6 – 8 hours
ONSET OF EFFECTS 30 – 90 minutes